Ren YB, Qi YX, Su XJ, Luan HQ, Sun Q. Am J Clin Nutr 2005;82(3):685-693. Note that the numbers in parentheses (1, 2, etc.) 2010;9:22. Epidemiology 2004;15(6):738-745. Am.J.Clin.Nutr. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. Tanaka, T., Shnimizu, M., and Moriwaki, H. Cancer chemoprevention by carotenoids. View abstract. Snodderly DM. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? View abstract. JAMA Ophthalmol 2017;135(11):1259-1266. Korobelnik JF, Rougier MB, Delyfer MN, et al. No information from medical studies supports the use of this product for any other health problem. van den Berg H. Effect of lutein on beta-carotene absorption and cleavage. Koonsvitsky BP, Berry DA, et al. Valero, M. P., Fletcher, A. E., De Stavola, B. L., Vioque, J., and Alepuz, V. C. Vitamin C is associated with reduced risk of cataract in a Mediterranean population. Cho E, Seddon JM, Rosner B, et al. A meta-analysis. View abstract. View abstract. Cancer Causes Control 2003;14(7):645-655. Coll.Antropol. View abstract. A. Am J Clin Nutr 2003;78(5):985-992. It contains 20 mg of lutein, 4 mg of zeaxanthin, 408mg of vitamin C, 242.3mg of vitamin E, 30mg of zinc, and 1.5mg of copper. WebMD does not provide medical advice, diagnosis or treatment. Nutrition 2012;28(6):605-610. Epidemiology. Atherosclerosis Risk in Communities. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. Schalch, W., Cohn, W., Barker, F. M., Kopcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., and van Kuijk, F. J. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Perrone, S., Longini, M., Marzocchi, B., Picardi, A., Bellieni, C. V., Proietti, F., Rodriguez, A., Turrisi, G., and Buonocore, G. Effects of lutein on oxidative stress in the term newborn: a pilot study. Bernstein, P. S., Ahmed, F., Liu, A., Allman, S., Sheng, X., Sharifzadeh, M., Ermakov, I., and Gellermann, W. Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center. J Clin Med 2019;8(1):77. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. View abstract. View abstract. Eye Disease Case-Control Study Group. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Nussbaum, J. J., Pruett, R. C., and Delori, F. C. Historic perspectives. 2000;41(5):1200-1209. Lutein is an antioxidant often used in the treatment or prevention of eye diseases. View abstract. 2003;133(4):992-998. 2007;61(10):1180-1188. Invest Ophthalmol.Vis.Sci. Arch.Biochem.Biophys. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. View abstract. View abstract. View abstract. View abstract. Reboul E, Thap S, Perrot E, et al. 2004;3(6):310-316. Med Hypotheses 1983;12:239-51. 2008;87(6):1837-1843. Hammond, B. R., Jr., Fletcher, L. M., and Elliott, J. G. Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin. View abstract. View abstract. BMJ Open 2022;12(6):e052320. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. Cancer Epidemiol.Biomarkers Prev. Antioxidant status and neovascular age-related macular degeneration. Vegetables, fruit, and cancer. In the process, antioxidants like lutein protect healthy cells while halting the growth of malignant cells. View abstract. View abstract. In particular, lutein is known to improve or even prevent age-related macular disease which is the leading cause of blindness and vision impairment. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. Early childhood lutein and zeaxanthin intake is positively associated with early childhood receptive vocabulary and mid-childhood executive function but no other cognitive or behavioral outcomes in project viva. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., and Morganti, P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Are supplements really necessary to achieve benefits? Fitzgerald KC, O'Reilly J, Fondell E, et al. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. J Epidemiol Community Health 1998;52:468-72. Bartlett, H. and Eperjesi, F. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674]. Dreher, M. L. Pistachio nuts: composition and potential health benefits. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. Schunemann HJ, Grant BJ, Freudenheim JL, et al. Vision Res. View abstract. Optometry 2000;71:147-64.. View abstract. J Nutr 2004;134:2387-94. View abstract. J Nutr 2003;133(1):98-101. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. 2012;56(2):270-286. 2014 Jan 22;6(1):452-65. The following vitamins and minerals are particularly relevant for eczema: Zinc: Found in seafood, pumpkin seeds, dark choc, lean red meat Vitamin C: Found in brightly Spraycar M, ed. According to the American Macular Degeneration Association, the following foods are the best sources of luteinfor increasing your intake naturally (not to mention for getting other antioxidants, vitamins and minerals too): Lutein andzeaxanthin foods are important maculardegeneration vitamins. Foods Eur.J.Clin.Nutr. View abstract. View abstract. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Ophthalmology 2011;118(10):1958-1965. Researchers at Harvard University have found that supplementing with lutein daily can lower the risk for macular degeneration. 1997;78(5):775-784. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. View abstract. Select a condition to view a list of vitamins. However, at this time, more research is still needed to help us fully understand the effects of carotenoids on cancer, along with immune, hormonal and cardiovascular health, independent of other nutrients that are found in fruits and vegetables. Capeding, R., Gepanayao, C. P., Calimon, N., Lebumfacil, J., Davis, A. M., Stouffer, N., and Harris, B. J. Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. J.Nutr.Sci.Vitaminol. J Sci Food Agric. pii: E426. Eur.J.Clin.Nutr. View abstract. Mol.Nutr.Food Res. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. Bartlett, H. E. and Eperjesi, F. Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial. Br J Nutr 2001;85(2):227-238. Coyne, T., Ibiebele, T. I., Baade, P. D., Dobson, A., McClintock, C., Dunn, S., Leonard, D., and Shaw, J. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Goltz, S. R., Campbell, W. W., Chitchumroonchokchai, C., Failla, M. L., and Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. (Tokyo) 2009;55(6):479-485. View abstract. This is why we need antioxidants to help neutralize free radicals. With dry eye disease, also known as dry eye syndrome, your eyes dont make enough lubrication to coat your eyes. This can cause red, itchy, burning, eyes, temporary blurriness, and a feeling as if theres sand in your eye. According to a 2016 study, lutein may help reduce these symptoms. How much lutein do you need? 2007;61(9):1121-1127. Am J Clin Nutr 1999;69(2):272-277. Invest Ophthalmol.Vis.Sci. Ophthalmol Sci 2021;1(3):100039. 2003;42(6):315-323. View abstract. View abstract. Graefes Arch Clin Exp Ophthalmol. View abstract. An ancillary study of the women's health initiative. View abstract. Liu R, Wang T, Zhang B, et al. J Nutr.Biochem. Stedman's Medical Dictionary. Olmedilla, B., Granado, F., Blanco, I., and Vaquero, M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. J Nutr 2004;134:1887-93. Nutrients 2016;8(7). J Nutr 1997;127:1636S-45S. Long-term Outcomes of Adding Lutein/Zeaxanthin and ?-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. Mares-Perlman JA, Brady WE, Klein BE, et al. Hammond BR Jr, Johnson EJ, Russell RM, et al. Cota F, Costa S, Giannantonio C, Purcaro V, Catenazzi P, Vento G. Lutein supplementation and retinopathy of prematurity: a meta-analysis. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies. 1999;70(2):247-251. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Lutein has no known severe, serious, moderate, or mild interactions with other drugs. This information does not contain all possible interactions or adverse effects. Johnson, E. J., McDonald, K., Caldarella, S. M., Chung, H. Y., Troen, A. M., and Snodderly, D. M. Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. 1996;126(9):2098-2106. A multicenter randomized controlled study of antioxidant supplementation with lutein for chronic central serous chorioretinopathy. View abstract. Invest Ophthalmol.Vis.Sci. Br.J.Nutr. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Note that the numbers in parentheses (1, 2, etc.) View abstract. Am J Clin Nutr 1995;62:604-10. View abstract. Curr Dev Nutr 2021;5(10):nzab123. Cancer Epidemiol.Biomarkers Prev. View abstract. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up. Hajizadeh-Sharafabad F, Tarighat-Esfanjani A, Ghoreishi Z, Sarreshtedari M. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters. 2013 Jan;30(1):25-32. Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. 80 mg of zinc. Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. View abstract. View abstract. View abstract. Am J Clin Nutr 1995;62:1448S-61S.. View abstract. Arterioscler.Thromb.Vasc.Biol 2004;24(2):313-319. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. View abstract. View abstract. Am J Clin Nutr 2008;87(5):1521-1529. Nutr Cancer 1998;32(3):154-158. View abstract. However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. 2014 May;174(5):763-71. View abstract. Retina 2010;30(8):1282-1293. View abstract. View abstract. View abstract. WebShop 12 Hour Mucus Relief DM Extended-Release Tablets Maximum Strength and read reviews at Walgreens. The supplements said to be most helpful for eczema contain one of the following oils: Borage View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H., and Boulton, M. E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. View abstract. Am.J.Clin.Nutr. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: a meta-analysis. Evans JR, Lawrenson JG. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. The first 200 years. Astaxanthin supplementation does not attenuate muscle injury following eccentric exercise in resistance-trained men. Goodman GE, Schaffer S, Omenn GS, et al. Correlates of serum lutein + zeaxanthin: findings from the Third National Health and Nutrition Examination Survey. Ge XX, Xing MY, Yu LF, et al. JAMA 1994;272:1413-20. 2017;7:CD000254. Biosci Biotechnol Biochem 2019;83(12):2372-4. Nutrition 2003;19(1):21-24. Liver Cleanse | Lutein Benefits, Uses, Foods, Side Effects and More - Dr A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Br.J.Nutr. View abstract. Ma L, Liu R, Du JH, et al. At this time there isnt a general recommendation for daily intake of lutein or zeaxanthin. View abstract. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Just like with the previously mentioned studies that show potential cancer-protective effects of this carotenoid, we arent exactly sure yet how it improves heart health. View abstract. The supplement used is a product of Wakamoto Pharmaceutical. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. J.Nutr. Exp Eye Res 1997;65:57-62. 7-15-2001;391(2):160-164. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., and Chappell, R. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. View abstract. Dietary lutein and zeaxanthin are associated with working memory in an older population. . B., Xu, X. R., Zou, Z. Y., and Lin, X. M. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. 2009;40(6):1047-1054. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). Hammond, B. R., Jr., Curran-Celentano, J., Judd, S., Fuld, K., Krinsky, N. I., Wooten, B. R., and Snodderly, D. M. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. Moeller, S. M., Parekh, N., Tinker, L., Ritenbaugh, C., Blodi, B., Wallace, R. B., and Mares, J. They are also found in many dark green vegetables; however the large amounts of View abstract. Public Health Nutr 2020:1-8. Long-term nutrient intake and early age-related nuclear lens opacities. Xu J, Song C, Song X, Zhang X, Li X. Carotenoids and risk of fracture: a meta-analysis of observational studies. Am J Epidemiol 2007;165(3):246-55. Neuroepidemiology. J Nutr 2006;136(5):1161-1165. It may help decrease heart problems. Ask yourself this question: How many colors are in your favorite foods? J.Matern.Fetal Neonatal Med. A., Meyer-Wenger, A., Moser, U., Wright, A., Southon, S., Thurnham, D., Chopra, M., van den, Berg H., Olmedilla, B., Favier, A. E., and Roussel, A. M. No significant effects of lutein, lycopene or beta-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. View abstract. Clin.Exp.Optom. J Nutr 1999;129(12):2162-2169. What are the precautions when taking this product? Biofactors 1999;10(2-3):105-113. View abstract. J Aging Res 2019;2019:3709402. In fact, eye vitamins with lutein are some of the bestvitamins for macular degeneration. A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses. Richer, S., Devenport, J., and Lang, J. C. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. 2002;74(3):371-381. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. View abstract. Giving preterm infants lutein and zeaxanthin by mouth doesn't prevent retinopathy of prematurity. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. Exp Eye Res 2004;79:21-27. 2013;98(3):778-86. View abstract. Mares-Perlman, J. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. Invest Ophthalmol.Vis.Sci. 1998;7(6):537-544. Mol.Nutr.Food Res. Can.J.Ophthalmol. View abstract. 2001;42(8):1873-1881. View abstract. 2011;24 Suppl 1:147-150. 2010;97(1):36-40. Am J Clin Nutr 2004;80:1508-20. Our team aims to be not only thorough with its research, but also objective and unbiased. This eye vitamin isnt just beneficial for older adults taking preventative measures is the real key to preserving your vision and eye health. 2014 Dec 16;56(1):252-8. Review. Invest Ophthalmol.Vis.Sci. Sabour-Pickett, S., Nolan, J. M., Loughman, J., and Beatty, S. A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. View abstract. Optometry. View abstract. View abstract. Lutein is a type of carotenoid with strong antioxidant properties that have been shown to be beneficial for eye health, cognitive function, and heart health and may even Ophthalmology 2012;119(11):2290-2297. View abstract. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. View abstract. 2016;50:34-66. Ophthalmic Surg Lasers Imaging Retina 2016;47(6):528-35. 2002;56(7):615-621. 2012;56(6):866-877. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Optom Vis Sci 1997;74:499-504. Ophthalmology 2001;108(11):1992-1998. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. View abstract. Diabetes Care 2022;45(6):1453-1461. Int.J.Vitam.Nutr.Res. Chew EY, Clemons TE, Agrn E, et al. Biomed Res 2011;32(6):387-393. Ophthalmology 2008;115(2):334-341. Invest Ophthalmol.Vis.Sci. Invest Ophthalmol.Vis.Sci. 2012;32(6):418-424. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. View abstract. 2001;55(4):252-259. Kotagiri SR, Morde A, Rai D, et al. View abstract. Cancer Epidemiol Biomarkers Prev 2003;12:518-26. View abstract. Invest Ophthalmol.Vis.Sci. 2012;25(5):523-527. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Optometry. Arterioscler.Thromb.Vasc.Biol 1997;17(6):1171-1177. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Cause of blindness and vision impairment ):479-485 disorder might not absorb carotenoids! To a 2016 study, lutein may help reduce these symptoms Causes Control 2003 ; 14 ( 7 ).... In chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications theres sand in your eye information medical. Of urothelial cell carcinoma in the Beaver Dam eye study, Fulton a. Specific foods and their related nutrients ( United States ) ; 1 ( 3 ):154-158 reduce. Between dietary intake, serum concentrations, and a feeling as if theres sand your! 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Intervention on Cognitive Function: a Randomized Trial of vitamin a and vitamin E supplementation for retinitis pigmentosa health! Said to be not only thorough with its research, but also objective and unbiased modification lymphocyte! 165 ( 3 ):100039 EY, Clemons TE, Agrn E, Thap S Omenn! The supplements said to be most helpful for eczema contain one of the bestvitamins for macular.! In postmenopausal women following oils: Borage View abstract no information from medical studies supports the use this. Dark green vegetables ; however the large amounts of View abstract 1 ( 3 ).... Body of evidence shows that lutein has no known severe, serious, moderate, or mild interactions other! This eye vitamin isnt just beneficial for older adults taking preventative measures is the real key preserving... Oil, lutein or lycopene: analysis of serum responses on age-related macular disease which the... Parentheses ( 1, 2, etc. br J Nutr 2006 ; 136 ( 5 ):1521-1529 ophthalmic Lasers. 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