IDSA Clinical Practice Guidelines are developed by a panel of experts who perform a systematic review of the available evidence and use the GRADE process to develop evidence-based recommendations to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances.. IDSA Clinical Guidance documents are Duration; Bacteremia without meningitis: All: Ampicillin plus gentamicin: 150-200mg/kg 7.5 mg/kg Initial treatment before culture results (48-72 hr) Penicillin G: 200,000 units/kg: Complete a total treatment course of 10 days Meningitis < 7 days: Ampicillin: 200-300 mg/kg/day in 3 divided doses: Initial treatment until CSF is sterile Gentamicin Bacteremia can be diagnosed using a blood culture.To do this, a sample of blood will be taken from a vein in your arm. Clin Infect Dis 2017. Pharmacotherapy 2015; 35:269. The optimal duration of antibiotic therapy for bloodstream infections is unknown. However, a randomized controlled trial including 604 Characteristic / 7 Genus Clostridium Gram-positive, spore-forming rods Obligate Anaerobes Box MJ, Sullivan EL, Ortwine KN, et al. Gram-negative bacteremia (39/59, 66.1%) and gram-positive bacteremia (10/24, 41.7%) were the most commonly identified BSI types in the first 2 weeks after VA ECMO implantation and after 3 weeks of VV implantation, respectively. The usual duration of treatment is 4 to 6 weeks; however, to avoid nephrotoxity and ototoxicity, a shorter course of aminoglycoside (2 weeks) may be recommended in some cases, e.g., small vegetarians or patients with native endocarditis without prosthetic valves. Medically Important Gram-Positive Bacilli hour duration No treatment Increasingly reported in immunosuppressed article. Enterobacteriaceae Bacteremia Retrospective, 3 -center, propensity score- matched cohort study Hospitalized adults with Enterobacteriaceae bacteremia Duration 6-10 days (median 8) vs. 11- 16 days (median 15 days) Chotiprasitsakul D, et al. Outcomes of rapid identification for gram-positive bacteremia in combination with antibiotic stewardship at a community-based hospital system. When queried about duration of total therapy for Gram-negative bacteremia, 64 of 557 reported treating for 7 days (11%), 234 reported treating from 8 to 13 days (42%), 254 reported treating for 14 days (46%), and 5 reported treating for more than 14 days (0.9%). The updated Tokyo Guidelines 2013 recommend a minimum duration of 2 weeks only when bacteremia with Gram-positive cocci is present. It will then be sent to a A minimum duration of 2 weeks is recommended for healthcare-associated cholangitis and cholecystitis (grades I-III) in patients with gram-positive coccal bacteremia. AHRQ Safety Program for Improving Antibiotic Use Acute Care Bacteremia 8 Slide Title and Commentary Slide Number and Slide Enterobacteriaceae Bacteremia: Treatment Duration Ten to 14 days has traditionally been used for the treatment of Gram-negative bacteremia. The Gram Positive Bacilli of Medical Importance Chapter 19 MCB 2010 Palm Beach State College Professor Tcherina Duncombe. Shorter durations of therapy have been demonstrated to be as effective as longer durations for many common infections; similar findings in bacteremia could enable hospitals to reduce antibiotic utilization, adverse events, resistance and costs. A search of the MEDLINE, EMBASE Pliakos EE, Andreatos N, Shehadeh F, et al. Since May 2013, a shorter antimicrobial treatment duration of under 2 weeks has been implemented at the authors' institution for acute cholangitis with Gram-negative bacillary bacteremia.