-Children up to 27 kg: 600,000 units IM every 3 to 4 weeks CONTRAINDICATIONS: US CDC Recommendations: -Treatment is not required if congenital syphilis is unlikely; use of this drug may be considered, especially if follow-up uncertain and neonate has reactive nontreponemal test. Note: Most individuals with chronic carriage do not require antibiotics. General: Penicillin G benzathine Dose in the treatment of acute Pharyngitis: Penicillin G benzathine Dose in the Secondary prophylaxis for rheumatic fever (prevention of recurrent attacks): Penicillin G benzathine Dose in the treatment of Chronic carriage (off-label): We use cookies to ensure that we give you the best experience on our website. PMID: 10498560 The manufacturer recommends that caution be exercised when administering penicillin to nursing women. Comments: -Infants and children with no clinical symptoms of congenital syphilis and whose evaluation (including CSF analysis) is normal: Use of this drug can be considered; a single dose can be considered after completing the recommended regimen (IV aqueous penicillin G for 10 days) to provide more comparable duration of therapy. -Current guidelines should be consulted for additional information. Granisetron (Sancuso) Uses, Dose, MOA, Brands, Side effects. Three doses of long acting Benzathine penicillin G (2.4 million units administered intramuscularly) at weekly intervals is recommended for individuals with late latent syphilis or latent syphilis of unknown duration. 1.2 million units IM once a month or 600,000 units IM every 2 weeks It can cause permanent neurological damage or gangrene. In patients with a severe penicillin allergy, it may not be feasible to use ceftriaxone. -Current guidelines should be consulted for additional information. Penicillin G benzathine (Penidure LA) is a long-acting formulation of penicillin for intramuscular use in the prevention of rheumatic fever and treatment of a variety of infections including syphilis. Usual Pediatric Dose for Syphilis - Latent. TREATMENT OF SYPHILIS Penicillin G (generic name) IM or IV is the preferred drug for treating all stages of syphilis. -If congenital syphilis possible, less likely, or unlikely: 50,000 units/kg IM as a single dose Some observational studies have suggested that this regimen may lead to high failure rates in coinfected patients. -Patients greater than 27 kg: 1.2 million units IM every 3 to 4 weeks Intramuscular benzathine benzylpenicillin is indicated in the treatment of infections due to penicillin-sensitive micro-organisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. Uses: For the treatment of mild to moderate upper respiratory tract infections (URTIs) due to susceptible group A streptococci (e.g., pharyngitis); for the treatment of URTIs (pharyngitis) due to group A streptococci (without bacteremia) Bicillin L-A: 2.4 million units IM once a week for 3 doses Intramuscular benzathine penicillin is the treatment of choice for syphilis. Caution is advised in patients with a history of seizure disorder; high levels, particularly in the presence of renal impairment, may increase the risk of seizures. Renal Impairment. CrossRef Yang CJ, Lee NY, Chen TC, et al. Applies to the following strengths: 1,200,000 units/2 mL; 600,000 units/mL; 2,400,000 units/4 mL. Alternative regimens in early syphilis patients with penicillin allergies include -Avoid missing doses and complete the entire course of therapy. Is recommended for the rest of her one and a half years until she could not anymore! 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